在丹麦基于登记册的队列中,配偶丧生的特定原因死亡率
Mathilde Marie Brünnich Sloth1,2, Johannes Hruza3, Laust Hvas Mortensen3,4,5
1Section of Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark. mathilde.sloth@sund.ku.dk.
Scientific reports
|February 20, 2025
概括
失去配偶增加了男性和女性因各种原因,特别是心血管疾病的死亡风险. 在配偶丧生后个性化死亡风险的预测模型的准确性有限.
科学领域:
- 老年学与公共卫生
- 流行病学 流行病学
- 生物统计学 生物统计学
背景情况:
- 配偶丧生是一个重要的生命事件,与所有原因死亡率的增加有关.
- 关于配偶丧生对因特定原因死亡率的影响的研究有限.
- 了解这些特定风险对于有针对性的干预和支持至关重要.
研究的目的:
- 估计配偶丧生对特定原因死亡率的平均影响.
- 开发和评估个人化死亡风险的预测模型.
- 分析死后死亡风险的性别差异.
主要方法:
- 一个匹配的队列研究,使用全国性的丹麦注册数据.
- 包括223,500名65岁及以上的已婚个人.
- 对于风险预测模型的平均因果效应估计和物流回归/极端梯度提升的G估计.
主要成果:
- 在男性中,悲伤显著增加了三年内因心血管疾病 (CVD),消化系统,精神病/自杀和呼吸系统疾病的死亡率.
- 女人经历了3年心血管疾病和精神病/自杀死亡率的增加.
- 在悲伤后的男性中观察到痴呆症/帕金森病的死亡率下降.
- 风险预测模型在确定个体因特定原因死亡率方面表现出有限的准确性.
结论:
- 配偶丧生与大多数死亡原因的风险略有增加有关,对男性的影响更大.
- 预测个体因特定原因死亡风险仍然具有挑战性,尽管有全面的数据.
- 需要进一步的研究,以改善风险预测,并制定有效的支持策略,为丧亲的个人.
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