肠道微生物群的饮食指数与糖尿病之间的关系
Zhe Wu1, Changle Gong2, Bin Wang3
1The First Clinical College, Shandong University of Traditional Chinese Medicine, Jinan, China.
更高的肠道微生物群 (DI-GM) 饮食指数得分与降低患糖尿病的风险有关. 保持DI-GM高于6.191可能是预防糖尿病的关键策略.
科学领域:
- 代谢健康和肠道微生物组.
- 营养流行病学和慢性疾病预防.
背景情况:
- 肠道微生物组在宿主新陈代谢中起着至关重要的作用.
- 肠道微生物群饮食指数 (DI-GM) 与糖尿病风险之间的关系需要进一步调查.
研究的目的:
- 探索DI-GM与糖尿病风险之间的关联.
- 确定潜在的门和受益于更高DI-GM的人口子组.
主要方法:
- 使用了国家健康和营养检查调查 (NHANES) 数据 (2007-2018).
- 采用多重物流回归,限制立方线 (RCS) 和值效应分析.
- 对敏感性和有针对性的见解进行了子组分析.
主要成果:
- 在DI-GM和糖尿病风险之间观察到显著的非线性负相关性 (P < 0.001).
- 确定了一个值效应:DI-GM低于6.191显示出与糖尿病风险有显著的负相关性.
- 保护性关联在各种人口和健康子组中是一致的.
结论:
- 更高的DI-GM与降低患糖尿病的风险非线性相关.
- 保持DI-GM得分高于6.191可能对预防糖尿病有好处.
- 针对肠道微生物群组成的饮食干预措施对代谢健康有希望.
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