在接受重大腹部手术的患者中,在治疗短暂的手术内低血压时,在服用埃弗德林和上腺素时,大脑氧化和血液动力学变化:随机对照试验
Xueyan Li1, Yijun Zheng1,2,3, Jun Zhang4,5,6
1Department of Anaesthesia and Critical Care, Fudan University Shanghai Cancer Center, Shanghai, 200032, PR China.
BMC anesthesiology
|February 20, 2025
概括
乙和乙都会在手术期间提高平均动脉压和中脑动脉速度. 然而,尽管对心脏输出量和心率有不同的影响,但这两种血管压缩剂都没有显著影响大脑氧化或自我调节.
科学领域:
- 麻醉学 麻醉学
- 关键护理医学 关键护理医学
- 神经外科 神经外科
背景情况:
- 在手术期间的低血压通常用乙烯和以弗得林治疗.
- 这些血管压缩剂对大脑氧化和血液流动的影响仍在争论中.
- 了解这些影响对于在手术期间的患者管理至关重要.
研究的目的:
- 为了研究烯和乙对大脑氧化和血液动力学的影响.
- 为了比较这两种血管压缩剂在接受重大腹部手术的成年患者中的作用.
- 评估它们对大脑自我调节指数的影响.
主要方法:
- 接受重大腹部手术的成年患者被随机分为乙 (ED) 或 (PE) 组.
- 静脉注射胆固醇用于治疗短暂的手术内低血压.
- 测量了区域大脑氧和 (rScO2),大脑血液动力学 (MCAvm,PI,RI),全身血液动力学 (ABP,HR,CO,CI,SV,SVI) 和大脑自身调节 (Mx_a,CO_x).
主要成果:
- 这两种药物都显著增加了平均动脉压 (MAP) 和中脑动脉速度 (MCAvm).
- 乙增加了心脏输出量 (CO) 和心率 (HR),而烯降低了它们.
- 在线性混合模型分析后,这两种药物都没有显著影响区域大脑氧和 (rScO2),Mx_a或CO_x.
结论:
- 乙和乙通过增加MAP和MCAvm有效地管理手术期间的低血压.
- 乙和乙之间的选择可能取决于它们对CO和HR的影响的差异.
- 这两种血管压缩剂似乎都没有显著改变大脑的氧化或自我调节.
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