与代谢功能障碍相关的脂肪肝相关的多方面的环境因素:一个环境范围的关联研究
Rui Dong1, Ting Tian2, Chen Ming3
1Department of Fundamental and Community Nursing, School of Nursing, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Jiangsu, 211166, China.
BMC public health
|February 20, 2025
概括
这项研究探讨了与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 相关的环境因素. 它确定了45个关键因素,包括一些鲜为人知的因素,为MAFLD预防和风险预测提供了洞察力.
科学领域:
- 环境健康 环境健康
- 代谢疾病 代谢疾病
- 流行病学 流行病学
背景情况:
- 环境因素 (暴露体) 对代谢功能障碍相关的脂肪肝疾病 (MAFLD) 有显著的贡献.
- 了解这些环境联系对于预防和管理MAFLD至关重要.
研究的目的:
- 调查美国成年人口中各种环境因素和MAFLD之间的关联.
- 通过全面的方法识别和验证对MAFLD的主要环境贡献者.
主要方法:
- 使用了国家健康和营养检查调查 (NHANES) 数据 (2005-2020年).
- 员工调查加权的多变量逻辑回归和LASSO回归用于因素识别和验证.
- 分析因素的重要性,歧视,相关性,子组差异和时间异质性.
主要成果:
- 包括14416名参与者;分析了511个候选环境因素.
- 确定并验证了167个因素,其中45个因素是在LASSO和相关性分析后选择的.
- 复制已知的因素并发现与MAFLD的新相关性,例如上腿的长度和获得护理.
结论:
- 这一环境范围的关联研究 (EWAS) 为与MAFLD相关的环境因素提供了广泛的视角.
- 这些发现为改善对MAFLD的理解,早期预防和风险预测策略提供了潜力.
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