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服用脱水氨可改善接受试管婴儿/ICSI治疗的女性的子宫内膜厚度:系统性审查和元分析

Ling Huang¹, Ying Gao², Shuo Liang³

¹School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China.

Journal of ovarian research

|February 20, 2025

概括

脱水素氨 (DHEA) 补充剂可以改善体内膜厚度和临床怀孕率在接受体外受精 (IVF) 的妇女. 然而,由于证据质量不佳和方法上的局限性,需要进一步的研究.

科学领域:

生殖内分泌学生殖内分泌学
不孕症治疗方法不孕症治疗方法
临床试验分析

背景情况:

脱氨 (DHEA) 正在研究其提高卵细胞和胚胎质量的潜力.
关于DHEA对辅助生殖技术中子宫内膜改善的影响的证据是不一致的.

研究的目的:

在体外受精/细胞内精子注射 (IVF/ICSI) 周期中系统地审查和元分析DHEA对子宫内膜功能和生殖结果的影响.
为在IVF/ICSI中使用DHEA提供基于证据的临床建议.

主要方法:

对并行控制的随机对照试验 (RCT) 的系统审查和元分析.
搜索了多个数据库 (PubMed,科克伦图书馆,EMBASE,科学网) 到2024年7月.
使用既有工具评估偏差风险和证据质量 (QoE);使用随机效应或固定效应模型分析结果.

主要成果:

DHEA治疗显著增加了子宫内膜厚度 (低QOE) 和临床怀孕率 (CPR) (低QOE).
卵细胞和胚胎质量指标得到改善,包括取出的卵细胞,受精的卵细胞,移植的胚胎和高质量的胚胎 (低至非常低的QOE).
结果的异质性可能与疾病类型,刺激方案和DHEA时间有关;对活产率的证据不足.

结论:

关于DHEA在IVF/ICSI中的作用的证据质量低至非常低,需要谨慎解释.
虽然DHEA可以通过改善心肺复苏来使患有薄子宫内膜的女性受益,但在广泛临床采用之前需要进行更严格的研究.
经过DHEA的使用,没有报告严重的不良反应.

关键词:

在体外受精/细胞内质精子注射.临床怀孕临床怀孕脱水氨酸和氨酸的脱水.子宫内膜厚度子宫内膜厚度活生生的出生是活生生的出生.

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