结肠,结肠直肠和所有癌症的发病率在年轻人中增加,这是由于附录的重新分类导致的
Archie Bleyer1,2, Lynn A G Ries3, Danielle B Cameron4
1Department of Radiation Medicine, Oregon Health and Science University, Portland, OR, USA.
Journal of the National Cancer Institute
|February 21, 2025
概括
将尾神经内分泌瘤 (NET) 重归类为恶性,在年轻人中人为地增加了癌症发病率. 这些附录NET在40岁以下的人中很少致命,因此不应纳入结直肠癌统计数据.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 癌症研究 癌症研究
背景情况:
- 在青少年和年轻成年人 (AYA) 中报告的结肠和结肠直肠癌的发病率上升.
- 这种增加可能是由于尾癌/神经内分泌瘤 (NET) 被重新归类为恶性瘤而产生的人工物.
研究的目的:
- 调查重新分类尾NET对AYA癌症发病率趋势的影响.
- 确定AYA中结肠和结肠直肠癌的实际发病率,不包括尾瘤.
主要方法:
- 利用来自监测,流行病学和最终结果 (SEER) SEER22数据库的年龄调整的发病率和生存数据.
- 分析了2000-2020年的癌症发病率趋势,将尾癌与AYA的其他癌症类型进行比较.
- 对被诊断患有恶性尾 NET 的AYA进行了检查的生存率.
主要成果:
- 从2000年到2020年,尾癌发生率在AYA中显著增加 (男性:12.8%AAPC,女性:14.6%AAPC).
- 尾癌/NET占所有年龄组尾癌增加的大部分.
- 在被诊断患有恶性附录NET (2010-2020) 的AYA患者中,癌症特异性6年生存率为99.4%.
结论:
- 附录NET/癌症类的重新分类为恶性有人工膨胀的结肠,结直肠和儿童和AYA的整体癌症发病率.
- 在40岁以下的个体中,NET很少是致命的,因此应排除在结直肠癌分析之外.
- 尾癌的人工增加可能会影响40-49岁成年人早期结直肠癌查的建议.
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