一个案例报告的碳甲基纤维素过敏:基于管理途径探索耐受性
Anays Piotin1,2, Anh Poirot1, Maxence Wurm1
1Division of Asthma and Allergy, Chest Diseases Department, Strasbourg University Hospital, Strasbourg, France.
Immunopharmacology and immunotoxicology
|February 21, 2025
概括
对碳甲基纤维素 (CMC) 的过敏性是可以管理的,因为耐受性因服用途径而异. 口服和眼滴形式是可以容忍的,但鼻腔CMC引起过敏反应,突出需要路线特定的测试.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 对诸如碳氧甲基纤维素 (CMC) 等辅助剂的过敏性带来了管理方面的挑战.
- CMC的无处不在使得过敏个体难以避免.
- 通过不同的途径评估CMC耐受性对于患者护理至关重要.
研究的目的:
- 评估证实CMC过敏的患者对碳甲基纤维素 (CMC) 的耐受性.
- 调查CMC过敏的路线依赖性.
- 审查关于CMC过敏和非注射途径耐受性的文献.
主要方法:
- 进行皮肤测试和基细胞激活测试以确认IgE介导的对CMC的过敏性.
- 使用CMC进行了口腔和鼻腔挑测试.
- 进行了文献审查,重点关注CMC过敏和非注射途径.
主要成果:
- 皮肤和基细胞测试证实了IgE介导的对CMC的过敏性.
- 患者可以耐受口服的CMC和含有CMC的眼滴.
- 用CMC引起的鼻挑导致喘恶化和鼻炎.
结论:
- 碳氧甲基纤维素 (CMC) 的耐受性取决于施用途径.
- 路线特定的挑测试对于管理CMC过敏至关重要.
- 对于CMC过敏患者的建议必须考虑给药途径.
更多相关视频
04:34Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
Published on: September 14, 2018
25.4K
05:41Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
Published on: April 6, 2022
2.6K
相关概念视频
Routes of Drug Administration: Enteral
3.2K
Medications can be administered through the enteral route using liquids, capsules, or tablets.
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
3.2K
Additional Routes of Drug Administration
2.7K
Choosing the appropriate route of drug administration is significantly influenced by two key factors: the therapeutic objectives and the inherent properties of the drug being used.
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
2.7K
Drug Delivery: Miscellaneous Routes
302
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
302
Drug Delivery: Enteral Route
369
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
369
Routes of Drug Administration: Overview
5.4K
Drug administration involves delivering drugs to the body through various routes, such as enteral, parenteral, and topical.
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
5.4K
Drug Delivery: Overview
271
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
271
