炎症和结直肠癌风险的生物标志物
Yuting Li1,2,3, Yuexin Luo4, Yue Ran5
1Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Frontiers in oncology
|February 21, 2025
概括
炎症与结直肠癌 (CRC) 风险有关,但像C反应蛋白 (CRP) 这样的炎症生物标志物显示出不一致的关联. 需要进一步的大型研究来澄清它们在CRC开发和预测中的作用.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 结肠直肠癌 (CRC) 是全球癌症死亡的主要原因.
- 炎症过程越来越多地被认为是它们在CRC启动和进展中的作用.
- 关于炎症生物标志物和CRC风险的现有研究存在不一致性,需要进一步调查.
研究的目的:
- 审查关键炎症生物标志物在结直肠癌 (CRC) 风险中的作用.
- 突出目前关于这些生物标志物的研究结果中的不一致性.
- 强调需要进行更大规模的前性研究,以澄清生物标志物与CRC的关联.
主要方法:
- 文献综述侧重于炎症生物标志物,如C反应蛋白 (CRP),IN-6 (IL-6) 和TNF-α.
- 探索阿迪波基因 (阿迪波涅克丁,莱普丁) 和它们与CRC的复杂关联.
- 讨论新兴的诊断技术,包括多omics和生物标志物与便隐性血液测试 (FOBTs) 的整合.
主要成果:
- 较高的C-反应蛋白 (CRP) 与瘤发生有关,但其与CRC风险的关联不一致,因性别和方法有所不同.
- 介乐-6 (IL-6),TNF-α,阿迪波内克丁和叶丁与CRC发展具有复杂的,有时是性别特异的关联.
- 非侵入性查方法,包括将生物标志物与iFOBT和多omics方法结合起来,显示出CRC诊断的前景.
结论:
- 炎症生物标志物在CRC风险预测中具有重要意义,但目前的证据不一致.
- 方法上的局限性和性别差异使生物标志物数据的解释变得复杂.
- 为了确定炎症生物标志物在CRC风险和诊断中的确切作用,需要进行更大规模的前性研究.
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