2012年至2023年发表的1425项不孕症试验的试验特征,地理分布和选定的方法问题:系统审查
Qian Feng1, Wanlin Li1, James Crispin1
1Department of Obstetrics and Gynaecology, Monash University, Clayton, VIC, Australia.
Human reproduction open
|February 21, 2025
概括
这项研究分析了从2012年到2023年的1425个不孕症随机对照试验 (RCT). 调查结果显示,人们专注于试管婴儿,初级结果不一致,研究出版的地理差异很大.
科学领域:
- 生殖医学 生殖医学
- 临床试验方法论 临床试验方法论
- 医疗保健服务研究 医疗服务研究
背景情况:
- 随机对照试验 (RCT) 对于评估不孕症干预措施至关重要.
- 了解不孕症的最新趋势RCT识别了研究缺口,并为未来的优先事项提供了信息.
- 本研究提供了对试验特征,地理分布和方法论问题的描述性分析.
研究的目的:
- 描述2012年至2023年期间发表的关于不孕症的随机对照试验 (RCT).
- 检查这些试验的地理分布.
- 在这些不孕不育RCT中识别选定的方法问题.
主要方法:
- 对Embase,Medline和Cochrane中央数据库对不孕症RCT进行系统审查 (2012年1月至2023年8月).
- 文本挖掘和手动提取试验特征,地理来源和方法方面 (注册,初级结果).
- 用于分析趋势的描述性统计数据,数据的准确性经过验证 (错误阳性/负性 ≤8%).
主要成果:
- 确定了1425个不孕不育RCT;69.6%专注于体外受精 (IVF).
- 中国 (22%),伊朗 (20%) 和埃及 (10%) 占所有试验的一半以上.
- 47.8%的试验未注册,37.6%缺乏指定的初级结果,尽管这些比例随着时间的推移而有所改善.
结论:
- 对试管婴儿的重视需要将研究重点转移到其他不孕症领域.
- 不平衡的地理分布引起了人们对通用性和公平的资源分配的担忧.
- 改善试验注册和初级结果规范是必不可少的,注册率取得了进展.
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