晚期肺癌炎症指数与喘患者全因和因特定死亡率之间的关联:一项队列研究
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Updated: May 27, 2025

Methodology for Sputum Induction and Laboratory Processing
Published on: December 17, 2017
Tu-Lei Tian1, Xiang-Kun Qu1, Hong-Bo Zhang1
1Department of Respiratory and Critical Care Medicine, The Affiliated Bozhou Hospital of Anhui Medical University, Bozhou, Anhui, China.
晚期肺癌炎症指数 (ALI) 与喘患者的死亡率降低有关. 较高的ALI得分显著降低了因所有原因和心血管疾病死亡的风险,表明其对预后的临床实用性.
科学领域:
- 肺部医学 肺部医学
- 心血管健康 心血管健康
- 生物统计学 生物统计学
背景情况:
- 在喘患者中,晚期肺癌炎症指数 (ALI) 的预后值仍然不清楚.
- ALI结合了炎症和营养状况,可能会影响疾病的结果.
研究的目的:
- 调查ALI与喘患者全因死亡率之间的关联.
- 评估ALI与特定原因死亡率之间的关系,包括心血管疾病 (CVD) 和癌症.
主要方法:
- 来自美国国家健康和营养检查调查 (NHANES) (1999-2018) 的4829名喘患者的分析.
- 利用考克斯的比例危险模型,限制立方线和竞争风险模型来评估ALI与死亡率的关联.
- 以人口统计和临床共变量进行调整.
主要成果:
- 在ALI和所有原因/心血管疾病死亡率之间发现了反向L形关联,并确定了值.
- 较高的ALI四分位数与显著降低的全因 (HR 0.51) 和心血管疾病死亡率 (HR 0.49) 相相关.
- 在ALI和癌症死亡率之间没有发现显著的关联.
结论:
- 在喘患者中,ALI与全因和心血管疾病死亡率相反相关.
- 在所有原因的82.02 (所有原因) 和58.40 (心血管疾病) 的ALI值以下,死亡风险较低.
- ALI可以作为喘患者的宝贵预后工具,特别是用于心血管风险评估.
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