与代谢功能障碍相关的脂肪性肝病的全球负担,2010年至2021年
Gong Feng1,2, Giovanni Targher3,4, Christopher D Byrne5
1Xi'an Medical University, Xi'an, China.
JHEP reports : innovation in hepatology
|February 21, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的全球健康问题,在科威特,埃及和卡塔尔的流行率很高. 意识和预防至关重要,特别是在中国,苏丹和印度,因为疾病的发病率迅速增加.
科学领域:
- 肝病学和胃肠病学 肝病学和胃肠学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 与代谢功能障碍相关的肥胖性肝病 (MASLD) 是一个重大且不断升级的全球健康挑战.
- 了解疾病的流行,发病率和残疾负担对于有效的公共卫生战略至关重要.
研究的目的:
- 从2010年到2021年分析MASLD的全球点患病率,年均发病率和残疾生活年 (YLDs).
- 为了比较不同地区,国家,年龄组,性别和社会人口统计指数 (SDI) 水平的MASLD负担.
- 在全球范围内确定MASLD的趋势和高负担领域.
主要方法:
- 利用了从2010年到2021年的全球疾病负担 (GBD) 数据.
- 在204个国家分析了MASLD的点患病率,年度发病率和YLDs.
- 采用平滑线模型来评估MASLD负担和SDI之间的关系,报告带有不确定性间隔 (UI) 的估计.
主要成果:
- 在2021年,全球年龄标准化的MASLD点患病率为15018.1/100,000,发病率为608.5/100,000,YLD为0.5/100,000.
- 患病率在男性 (15,731.4/100,000) 比女性 (14,310.6/100,000) 高,在45-54岁年龄段达到顶峰.
- 科威特,埃及和卡塔尔的患病率最高;中国,苏丹和印度的患病率增长最大 (2010-2021年).
结论:
- MASLD是一个全球性的健康问题,在流行率和发病率方面存在显著的区域差异.
- 有针对性的预防和宣传活动至关重要,特别是在发病率高的地区,如中国,苏丹和印度.
- 建议进行进一步的研究,以验证在临床环境中的建模结果.
更多相关视频
相关概念视频
01:24Overview of Lipid Metabolism
938
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
938
01:26Diseases of the Liver and Gallbladder
411
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
411
01:30Liver Physiology
411
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
411
01:19Overview of Carbohydrate Metabolism
676
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
676
01:24Liver Regeneration
3.2K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.2K
01:24Obesity
362
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
362