左心房附属体封闭:背后的出血风险.
Giovanni Lorenzoni1, Pierluigi Merella1, Gavino Casu1
1S.C. Cardiologia Clinica e Interventistica, A.O.U. Sassari, Sassari, Italy.
概括
心房动增加了中风的风险. 左心房尾阻塞 (LAAO) 为预防非膜心房动 (NVAF) 的中风提供了替代口服抗凝剂的替代方案,即使是在患有非膜心脏动的患者中也是如此.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 医疗器械 医疗器械
背景情况:
- 心房动 (AF) 是一种普遍的心律失常,与栓性中风的更高风险有关.
- 口服抗凝药疗法 (OAT) 是预防AF患者脑栓塞事件的主要策略.
- 非膜性心房动 (NVAF) 患者可能会经历缺血性中风,尽管足够的OAT.
研究的目的:
- 探索左心室尾阻塞 (LAAO) 作为NVAF患者缺血性中风的二次预防策略的作用.
- 讨论LAAO在患有"抗性中风"的患者的挑战和考虑,尽管OAT.
主要方法:
- 对比LAAO和OAT用于NVAF中风预防的临床试验的综述.
- 对OAT.在NVAF患者中风发生的生理病理学理论的分析.
- 评估LAAO作为二次中风预防的治疗选择.
主要成果:
- 在预防NVAF患者中风方面,LAAO已经证明与OAT无劣.
- 在接受OAT的NVAF患者中发生中风的确切原因 ("耐药性中风") 尚未完全理解.
- LAAO是一种可行的选择,需要对患者进行仔细的选择和规划.
结论:
- 在NVAF中,LAAO是OAT用于预防中风的证明替代品.
- 需要进一步的研究来阐明"抗性中风"的机制.
- 在选择的NVAF患者中,可以成功地进行LAAO,以减少中风风险.
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