患有自身免疫神经疾病的患者肠道微生物组合的乱:系统性审查和元分析
Xiaolin Deng1,2, Xue Gong1,2, Dong Zhou1
1Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Frontiers in immunology
|February 21, 2025
概括
肠道疾病与自身免疫神经系统疾病有关. 这次审查发现患者的有益细菌减少,病原体增加,这表明在各种疾病中都有共同的微生物变化.
科学领域:
- 神经免疫学 神经免疫学
- 微生物组研究 微生物组研究
- 自身免疫性疾病 自身免疫性疾病
背景情况:
- 肠道疾病越来越多地与自身免疫神经系统疾病有关.
- 要了解这种关系,需要对现有证据进行全面的综合分析.
- 这次系统性审查和元分析解决了这一差距.
研究的目的:
- 系统地审查和元分析肠道微生物群和自身免疫神经系统疾病之间的相关性.
- 为这些疾病提供临床诊断和治疗干预的信息.
主要方法:
- 在PubMed,Embase,Web of Science和Cochrane图书馆搜索到2024年3月.
- 包括62项研究,包括来自3,126名患者和2,843名健康个体的数据.
- 分析了α-多样性,β-多样性和特定的细菌种群.
主要成果:
- 阿尔法多样性显示Chao1指数略有下降;其他指数没有显著变化.
- 贝塔多样性差异仅在神经脊髓炎光学谱系障碍中一致.
- 在多种自身免疫神经疾病中观察到减少短链脂肪酸 (SCFA) 生产细菌 (例如,Faecalibacterium,Roseburia) 和增加病原体 (例如,Streptococcus,Escherichia-Shigella).
结论:
- 肠道微生物群的干扰与自身免疫神经系统疾病有关.
- 结果表明非特异性,共享的微生物变化,包括减少SCFA生产者和增加病原体.
- 这些见解可以指导未来的诊断和治疗策略.
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