接受长期性别肯定激素治疗的老年跨性别个体的认知功能
Jason O van Heesewijk1,2,3, Koen M A Dreijerink1,2, Chantal M Wiepjes1,2
1Endocrinology, Amsterdam UMC location Vrije Universiteit, Amsterdam, The Netherlands.
International journal of transgender health
|February 21, 2025
概括
较年长的跨性别女性的认知功能低于 cisgender 群体,主要是由于心理/社会健康因素. 跨性别男性的认知差异很小,这表明没有显著的长期激素治疗效果.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 内分泌学 在内分泌学.
背景情况:
- 认知功能随着年龄的增长而下降,心血管风险 (CVR) 和心理健康问题.
- 性激素可能提供神经保护.
- 关于老年跨性别者长期接受性别肯定激素治疗 (GHT) 的认知功能的数据有限.
研究的目的:
- 在较大的老年跨性别和 cisgender 个体样本中评估认知差异.
- 确定CVR和心理/社会健康对这些认知差异的贡献.
主要方法:
- 横截面研究比较了73名跨性别女性和39名跨性别男性 (年龄在56-84岁) 接受GHT与匹配的cisgender对照.
- 通过神经心理测试评估认知功能.
- 线性回归分析了平均z分数,调整了CVR和心理/社会健康因素.
主要成果:
- 跨性别女性在信息处理速度,情节性记忆和结晶智力方面得分低于 cisgender 群体.
- 跨性别男性的情节性记忆比异性女性低,但与异性男性相似.
- 心理/社会健康因素,特别是抑郁症状,在很大程度上解释了认知差异,而CVR因素的影响较小.
结论:
- 跨性别男性的最小认知差异表明没有显著的长期丸激素效应.
- 变性女性的认知功能低下主要与心理/社会健康有关.
- 进一步的研究和临床关注老年跨性别者的心理和认知健康是有必要的.
更多相关视频
相关概念视频
01:30Cognitive Development During Adulthood
45
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
45
01:28Menopause
117
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
117
01:26Aging
35
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
35
01:18Cognitive Development During Adolescence
39
During adolescence, individuals experience significant cognitive development that enhances their understanding of others' emotions and thoughts, known as cognitive empathy. This period is marked by an increased ability to adapt to others' perspectives and a more nuanced understanding of others' mental states, a skill that is foundational for social problem-solving and conflict avoidance. The development of cognitive empathy relies heavily on the theory of mind — the...
39
01:30Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
95
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
95
01:30Negative and Cognitive Symptoms of Schizophrenia
40
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
40