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评估慢性病患者的功能,有或没有甲状腺功能低下症
Pujitha Mallina1, Vinay Rajan2, Eswar Kumar2
1M.Pharm-Pharmacy Practice, A.U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, 530003.
Ethiopian journal of health sciences
|February 21, 2025
概括
甲状腺功能低下会使慢性病 (CKD) 患者的功能恶化. 那些患有甲状腺功能低下症的人表现出较高的肌素,尿素,BUN和,估计的淋巴膜过率 (eGFR) 较低.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 甲状腺功能低下症是一种常见的内分泌疾病,与慢性病 (CKD) 有着已知的双向关系.
- 甲状腺功能低下症对已经被诊断患有CKD的人来说是一个显著的并发症.
- 这两种疾病之间的相互作用需要进一步研究它们对功能的影响.
研究的目的:
- 研究甲状腺功能低下对慢性病患者功能障碍进展的影响.
- 为了比较CKD患者和没有甲状腺功能低下症之间的功能标志物.
主要方法:
- 研究了150名参与者的队列,包括110名没有甲状腺功能低下症的CKD患者和40名甲状腺功能低下症的CKD患者.
- 参与者根据估计的淋巴细胞过率 (eGFR) 分为CKD第3,4和5期.
- 关键的临床和人口统计数据,包括血清肌素,尿素,BUN,eGFR和电解质,在三个月的时间内进行了监测.
主要成果:
- 患有甲状腺功能低下症的CKD患者与没有甲状腺功能低下症的患者相比,血清肌素,尿素和血液尿素 (BUN) 水平显著提高.
- 在患有甲状腺功能低下的CKD患者中观察到估计的显著较低的淋巴膜过率 (eGFR) (P < 0.0001).
- 在甲状腺功能低下症组 (P = 0.0001) 发现水平升高,而和水平没有显著差异.
结论:
- 甲状腺功能下降症与慢性病患者中功能下降的程度更为明显.
- 这些发现强调了甲状腺状况在CKD背景下对脏健康的关键影响.
- 治疗甲状腺功能低下症可能对保持CKD患者功能至关重要.
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