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在自身免疫介导的风湿性疾病中急性损伤

Daniel Patschan^1,2, Gerhard Schmalz³, Wajima Safi¹

¹Department of Internal Medicine I - Cardiology, Nephrology and Internal Intensive Medicine, Brandenburg Medical School (Theodor Fontane), University Hospital Brandenburg, Brandenburg 14770, Germany.

Journal of clinical medicine research

|February 21, 2025

概括

急性损伤 (AKI) 对住院患有炎症性类风湿性疾病的患者来说是一个日益关注的问题. 虽然直接损伤很少见,但某些类风湿症和像NSAIDs这样的药物会增加AKI风险.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
类风湿病学类风湿病学
内部医学内部医学

背景情况:

急性损伤 (AKI) 是全球住院患者的一个重大临床挑战.
患有炎症性类风湿性疾病的患者面临AKI的独特风险,不仅仅是关节和肌肉的参与.
了解这些风险对于患者的管理和结果至关重要.

研究的目的:

审查和综合有关炎症性类风湿性疾病患者AKI的原因和模式的文献.
为了确定特定的类风湿性疾病和与增加AKI风险相关的药物.
强调需要进一步研究独立于直接病理学的AKI风险因素.

主要方法:

1958年至2024年间发表的综合叙事综述研究.
在主要的科学数据库中进行了搜索:PubMed,科学网,Cochrane图书馆和Scopus.
专注于确定炎症性类风湿性疾病,药物和AKI发展之间的关联.

主要成果:

虽然常见的疾病如类风湿性关节炎很少直接导致AKI,但某些炎症性类风湿性疾病与特定的病理有关.
经常用于疼痛和炎症的非类固醇抗炎药物 (NSAIDs) 被确定为AKI的潜在原因,包括急性管状缩.
新出现的证据表明,一些类风湿性疾病可能会独立于直接脏影响而提高AKI风险,尽管数据仍然有限.

结论:

AKI对患有炎症性类风湿性疾病的人来说是一个相当大的威胁.
需要进一步研究以阐明与这些疾病相关的AKI风险的机制和程度,特别是不直接涉及结构的因素.
需要加强意识和研究,以减轻AKI在这个脆弱的患者群体.

关键词:

艾基 (AKI) 是一个人.在DMARD治疗中使用DMARD治疗.淋巴细胞突炎是什么?没有NSAID可以治疗.类风湿性疾病是一种类风湿性疾病.

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