相关实验视频
Updated: May 5, 2026

05:22
Iris Fixation via External Pentagram Suturing
Published on: May 5, 2022
1.2K
轨道免疫球蛋白G4相关疾病的周围神经传播:一个病例报告
Harshini Sirvisetty1, Samuel Bockhorst1, Ramin Hamidi2
1Department of Radiology, University of Louisville School of Medicine, Louisville, USA.
Cureus
|February 21, 2025
概括
免疫球蛋白G4相关疾病 (IgG4-RD) 是一种罕见的疾病. 这一案例突出显示,在其他疗法失败后,使用阿扎西奥普林成功治疗轨道IgG4-RD与周围神经扩散.
科学领域:
- 免疫学 免疫学 免疫学
- 神经学 神经学
- 眼科医生 眼科 眼科
背景情况:
- 免疫球蛋白G4相关疾病 (IgG4-RD) 是一种罕见的纤维炎症疾病,影响多个器官.
- 由于意识有限和临床表现多样化,诊断具有挑战性.
- 周围神经扩散的轨道参与是一种不常见的表现.
研究的目的:
- 报告一个罕见的轨道IgG4-RD与周围神经传播的病例.
- 讨论管理IgG4-RD的诊断和治疗方面的挑战.
- 强调需要个性化治疗策略的需要.
主要方法:
- 一位老年妇女的病例介绍,两侧轨道IgG4-RD和三角神经受损.
- 对IgG4水平升高的血清检测和成像研究 (MRI).
- 对普得尼松,利图西马布和阿扎西奥普林的治疗反应的审查.
主要成果:
- 显著升高的血清IgG4水平和成像检查证实了轨道炎症和周围神经扩散.
- 对普得尼松的初始反应,随后对rituximab的过敏反应.
- 用阿扎西奥普林成功控制疾病和缓解症状,使IgG4水平正常化.
结论:
- 当其他选择失败时,阿扎西奥普林可以有效治疗IgG4-RD.
- 识别IgG4-RD对于诊断轨道和神经症状至关重要.
- 需要对罕见的表现,如周围神经扩散进行进一步的研究.
相关概念视频
Encephalitis l: Introduction
27
Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
27
Encephalitis ll: Pathophysiology
30
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
30

