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氧化诱导的心肌病:一个病例报告
Ahmed Hussein1, Aya Salih2, Tebyan Mohammedali2
1Pathology and Laboratory Medicine, University of Texas Health Science Center, McGovern Medical School, Houston, USA.
Cureus
|February 21, 2025
概括
氧化 (HCQ) 可以引起严重的心肌病,这是一个罕见但严重的副作用. 这一案例突出了HCQ诱导的心脏病中的心脏成像和病理学发现,强调了患有不明原因心力衰竭的患者需要提高意识的必要性.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 病理学 病理学 病理学
背景情况:
- 基氨酸 (HCQ) 是一种免疫调节药物,它倾向于在溶酶体中积聚.
- 由HCQ改变溶解体pH值可能会损害酶功能,导致细胞损伤.
- 心肌病是一种已知的,尽管很少见的,长期使用HCQ的并发症.
研究的目的:
- 要呈现一种严重的氧化诱导心肌病的病例.
- 为了说明心脏成像特征的发现.
- 详细说明由内心肌活检确认的病理特征.
主要方法:
- 一个76岁的患有Sjögren病的妇女在长期HCQ的病例介绍.
- 心声图和心脏MRI用于评估心脏结构和功能.
- 用光和电子显微镜进行心内膜活检,包括特殊染料.
主要成果:
- 心脏MRI显示非缺血性晚期加多增强,左心室壁加厚,双心室低运动.
- 光显微镜揭示了肌细胞真空化与PAS阳性含有敏感于扩散的含有.
- 电子显微镜证实了髓状和曲线形体的存在,诊断HCQ毒性.
结论:
- 氧化诱导的心肌病是一种罕见的,可能致命的疾病.
- 特征性成像和病理发现有助于诊断.
- 临床医生应考虑长期使用后患有无法解释的心脏功能障碍的患者的HCQ毒性.
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