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国家卫生研究院的癌症和加速衰老研究,2013-2023年:一项资助组合分析
Lisa Gallicchio1, Rachelle Brick2, Gina Tesauro3
1Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, Maryland, USA.
Journal of the American Geriatrics Society
|February 21, 2025
概括
美国国家卫生研究院 (NIH) 对癌症和衰老研究的资金增加了,但差距仍然存在. 需要更多的研究来了解癌症幸存者的加速衰老,并开发干预措施.
科学领域:
- 老年病学和瘤学
- 生物医学研究资助
- 癌症的生存率 癌症的生存率
背景情况:
- 国家卫生研究院 (NIH) 资助癌症和衰老的研究.
- 了解癌症生存率和加快衰老的交叉关系至关重要.
研究的目的:
- 描述NIH资助的赠款组合,专注于癌症幸存者和加速衰老.
- 从2013-2023财政年度确定该研究领域的趋势和资金模式.
主要方法:
- 利用了NIH研究,条件和疾病分类 (RCDC) 系统的文本挖掘.
- 应用癌症生存率和与衰老相关的术语 (例如,衰老,神经认知,身体功能).
- 双重编码166个新资助的资助,以提取研究特征.
主要成果:
- 国家癌症研究所 (NCI) 和国家衰老研究所 (NIA) 资助了大部分赠款 (62.0%和23.5%).
- 新资助的赠款从2013年的9个增加到2023年的27个.
- 大多数研究是观察性的 (65.1%),检查了认知/身体功能 (54.4%/37.5%),并纳入了衰老生物标志物 (30%).
- 很少有资助专注于少数民族或农村癌症幸存者 (3.0%/2.4%).
结论:
- 美国国家卫生研究院 (NIH) 对癌症和加速衰老研究的资金有所增加,但仍存在重大差距.
- 有必要研究癌症幸存者的加速衰老表型和机制.
- 需要采取干预措施来识别和支持高风险的幸存者,对不良的衰老影响.
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