指纹与原始和加工的果提取物的抗炎和抗咳活动之间的频谱效应关系
Zhenguo Lv1,2, Wenhan Lin2, Omachi Daniel Ogaji2
1First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Biomedical chromatography : BMC
|February 21, 2025
概括
这项研究将Mume Fructus (MF) 提取物的化学特征与其抗炎和抗咳作用联系起来. 特定的化合物被确定为这些药用特性的主要贡献者.
科学领域:
- 药理学和植物化学
- 自然产品分析 自然产品分析
- 传统医学的传统医学.
背景情况:
- 果 (Mume Fructus,简称MF) 广泛用于医学和饮食,其原始和加工形式都有临床应用.
- 了解MF生物活性的化学基础对于其药用和食用途至关重要.
- 建立MF的化学成分与其治疗作用之间的联系对于合理的药物发现至关重要.
研究的目的:
- 为了确定UHPLC-Q-TOF-MS/MS指纹与原始和加工的MF提取物的抗炎和抗作用之间的频谱效应关系.
- 确定负责观察到的药理作用的关键生物活性成分.
- 开发一个模型来研究MF提取物的频谱效应关系.
主要方法:
- 超高性能液态染色学与四极双极飞行时间质谱学 (UHPLC-Q-TOF-MS/MS) 结合使用,用于指纹采集.
- 生物活性测试用于评估抗炎和抗咳作用.
- 灰色关系分析和部分最小平方回归用于选活性成分.
主要成果:
- 在MF提取物的UHPLC-Q-TOF-MS/MS指纹中发现了21个常见的峰值.
- 原料和加工的MF提取物显示出不同的抗炎和抗咳活性.
- 九个成分与抗炎作用 (例如,酸,酸) 和三种抗咳活性 (例如,杏仁素,酸) 有关.
结论:
- 一个将UHPLC-Q-TOF-MS/MS指纹与生物活性相结合的模型成功地开发了MF提取物.
- 特定的化合物被确定为MF的抗炎和抗咳性质的药理学活性贡献者.
- 这些发现为发现生物活性成分和合理化Mume Fructus的临床使用提供了基础.
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