针治疗新生儿戒断综合征的新生儿
Berndt Urlesberger1, Rita Cabano2, Greg Soll3
1Division of Neonatology, Medical University Graz, Graz, Austria.
The Cochrane database of systematic reviews
|February 21, 2025
概括
针对新生儿戒断综合征 (NAS) 没有明显的好处,这是新生儿药物戒断的情况. 需要更多的研究来确定针是否有效治疗NAS症状或减少住院时间.
科学领域:
- 新生儿护理 新生儿护理
- 综合医学是一个整体的医学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 新生儿戒断综合征 (NAS) 是新生儿由于产前暴露于药物,主要是阿片类药物的戒断综合征.
- 纳斯需要医疗治疗和长时间住院,目前的管理策略正在讨论中.
- 针,涉及针插入或非穿透的技术,如针和激光,被探索作为一个潜在的干预NAS.
研究的目的:
- 评估针 (针,针,激光) 在减少新生儿戒断综合征 (NAS) 治疗时间,不良事件和住院期间的疗效.
主要方法:
- 对随机对照试验 (RCT),准RCT和集群随机试验进行了系统审查.
- 研究包括在出生后72小时内被诊断患有NAS的婴儿,将针与没有干预,安慰剂,假药治疗或药物治疗进行比较.
- 主要结局包括药理治疗的持续时间,不良事件和住院时间,证据确定性使用GRADE进行评估.
主要成果:
- 两项涉及104名婴儿的RCT比较了非侵入性针加标准护理与单独标准护理.
- 有关针对药物治疗持续时间,不良事件和住院时间的影响的证据非常不确定.
- 没有研究报告了所有原因死亡率,疼痛或长期随访的数据;在包括的研究中没有报告任何不良影响.
结论:
- 来自小样本的有限证据不足以确定针对NAS管理的好处或危害.
- 临床医生应谨慎地对待NAS的针,因为缺乏常规应用的支持性证据.
- 需要进一步的大规模,经过良好的RCT来评估针在治疗NAS中的有效性和安全性.
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