成年人脑癌发病率模式:日本和日裔美国人的比较研究
Byron Sigel1, Diana R Withrow2, Lene H S Veiga3
1Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
International journal of cancer
|February 21, 2025
概括
脑部和中枢神经系统 (CNS) 瘤的发病率在日裔和日裔美国人中低于美国非西班牙裔白人和亚裔美国人/太平洋岛民. 这表明在中枢神经系统瘤发育中可能有遗传作用.
科学领域:
- 神经瘤学神经瘤学
- 流行病学 流行病学
- 遗传学 是一个遗传学.
背景情况:
- 成人原发性大脑和中枢神经系统 (CNS) 癌症罕见但致命,全球发病率差异很大.
- 美国的病率很高,因种族而异,而日本的病率较低.
研究的目的:
- 将日本和日裔美国人与美国非西班牙裔白人 (NHW) 和亚裔美国人/太平洋岛民 (AAPI) 的恶性中枢神经系统瘤发病率进行比较.
- 通过检查基于人口的发病率来调查中枢神经系统瘤的潜在遗传和环境风险因素.
主要方法:
- 利用了来自日本癌症发病率监测 (MCIJ) 和美国监测,流行病学和最终结果 (SEER) -9注册表 (2007-2014) 的数据.
- 计算中枢神经系统瘤的年龄标准化发病率 (ASR),按年龄,性别和瘤亚型分层.
主要成果:
- 日本人 (ASR: 3.66) 和日裔美国人 (ASR: 2.5) 的中枢神经系统瘤发病率明显低于美国NHW (ASR: 9.43) 和AAPI (ASR: 4.13) 的中枢神经系统瘤发病率.
- 这种发病率模式在瘤亚型,年龄组和性别中持续存在.
结论:
- 这些发现支持一种影响发展大脑和中枢神经系统瘤的风险的遗传成分.
- 在不同人群中比较发病率有助于理解中枢神经系统瘤发生过程中遗传和环境因素的相互作用.
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