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长期COVID的动物模型:当前的进展,局限性和未来的方向

Yu Zhang¹, Huan Chen², Yumeng Li¹

¹Department of Biosafety, School of Basic Medicine, Army Medical University, Chongqing, China.

Journal of medical virology

|February 21, 2025

概括

长期COVID (LC) 是一种慢性,残疾的疾病,需要更好的动物模型. 本综述评估了当前复制LC症状的模型,并指导未来研究有效治疗方法.

科学领域:

病毒学病毒学
免疫学免疫学免疫学
病理学病理学病理学

背景情况:

长期COVID (LC) 是一个重要的公共卫生问题,具有慢性,全身和致残的影响.
了解LC机制需要进行基础的科学研究来开发治疗方法.
对于精确模仿人类LC临床特征的动物模型有着至关重要的需求.

研究的目的:

通过使用临床流行病学数据,审查受LC影响的肺外系统的病理变化.
批判性地评估现有的动物模型 (非人类灵长类动物,小鼠,仓鼠) 对于它们复制持续LC症状的能力.
确定在开发下一代动物模型中需要改进的领域,用于LC研究.

主要方法:

对长期COVID的临床流行病学数据的整合.
对当前用于长期COVID症状复制的动物模型进行批判性检查.
确定慢性后病毒综合征的动物模型开发中的研究缺口.

主要成果:

慢性肺炎会影响多个肺外系统,有病理变化的记录.
现有的动物模型显示在完全回顾人类LC的多样性和持久性症状方面存在局限性.
确定了提高动物模型对人类LC表现的忠诚度的具体领域.

结论:

改进的动物模型对于推进长期COVID研究至关重要.
下一代模型将加速对病毒感染慢性病的理解.
增强型模型对于疫情准备和制定有效的治疗策略至关重要.

关键词:

根据COVID-19的情况,长时间的COVID.在SARS-CoV-2中.动物模型动物模型

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