基于光疗的NIR-II吸收光敏剂对过敏性鼻炎的双边协同效应

相关实验视频

Updated: May 26, 2025

Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination

Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination

Published on: February 9, 2021

Tao Shao¹, Lu Han², Yang Xie²

¹State Key Laboratory of Flexible Electronics (LoFE) & Institute of Flexible Electronics (IFE), Northwestern Polytechnical University, Xi'an, 710072, China.

Small (Weinheim an der Bergstrasse, Germany)

|February 21, 2025

概括

新的纳米粒子为过敏性鼻炎 (AR) 提供了一种新的光疗方法. 这种治疗使用轻度光热和光动力学疗法来减少过敏反应,为当前药物提供更安全,更有效的替代品.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
免疫学免疫学免疫学

背景情况:

过敏性鼻炎 (AR) 影响全球30亿人,发病率越来越高.
目前针对AR的药物疗法有效性有限,副作用很大.
对于有效的AR管理,需要新的治疗策略.

研究的目的:

开发基于aza-BODIPY的纳米粒子 (RH@NP) 用于联合光热疗法 (PTT) 和光动力疗法 (PDT).
在AR的小鼠模型中研究RH@NP的协同治疗效应.
阐明光疗在AR治疗中的潜在机制.

主要方法:

基于aza-BODIPY的纳米粒子 (RH@NP) 的合成,具有增强的NIR-II吸收.
使用RH@NPs的PTT和I型PDT在小鼠AR治疗中的应用.
对表皮细胞-介质细胞转换 (EMT) 相关基因和NRF2转录活性表观遗传调节的分析.

主要成果:

RH@NPs表现出协同的PTT和PDT效应,在小鼠模型中显著减少过敏反应.
PTT增强了HSF1的DNA结合活性,通过表观遗传调节相关基因来抑制EMT.
PDT激活了NRF2的转录活性,刺激了抗氧化剂防御系统.
与传统治疗相比,光疗方法的安全性得到了提高.

结论:

RH@NPs通过机械减少过敏反应,为AR提供了一种新且有效的物理治疗方法.
这项研究是第一个探索AR光疗的研究,详细介绍了它的作用机制.
开发的基于光敏感剂的疗法为AR提供了简单有效的治疗策略.

关键词:

过敏性鼻炎过敏性鼻炎 aza-BODIPYYY 的意思是身体.接近红外II的吸收光动力学疗法是一种光动力学疗法.光热疗法是一种光热疗法.

更多相关视频

Method for the Assessment of Effects of a Range of Wavelengths and Intensities of Red/near-infrared Light Therapy on Oxidative Stress In Vitro

Method for the Assessment of Effects of a Range of Wavelengths and Intensities of Red/near-infrared Light Therapy on Oxidative Stress In Vitro

Published on: March 21, 2015

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence

Published on: September 22, 2023

相关概念视频

Combined Effects of Drugs: Synergism

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...

Allergic Drug Reactions

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...