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3D关节T1/T1 ρ/T2映射和水脂肪成像用于在1.5T时对比剂免费心肌组织的表征
Michael G Crabb1, Karl P Kunze1,2, Simon J Littlewood1
1School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Magnetic resonance in medicine
|February 21, 2025
概括
一种新的7分钟MRI技术提供了3DT1,T2和T2*映射和水脂肪成像. 这种没有对比剂的方法可以进行全面的心肌组织表征和全心解剖评估.
科学领域:
- 心血管磁共振成像 - 心血管磁共振成像
- 生物医学工程 生物医学工程
- 医学物理 医学物理
背景情况:
- 心肌组织的表征对于诊断心血管疾病至关重要.
- 传统的MRI技术往往需要对比剂和多次扫描,限制了全面的评估.
- 自由呼吸,全心成像与同时多参数映射仍然是一个挑战.
研究的目的:
- 使用迪克森编码开发一种新的,自由呼吸的3D联合T1/T2/T2*映射序列.
- 为了在单个7分钟的扫描中获得共同注册的3DT1,T2和T2*地图和水脂体积.
- 为了使没有对比剂的心肌组织表征和全心解剖评估具有同位素分辨率.
主要方法:
- 为T1,T2和T2*编码开发了超过5次心跳的交错序列.
- 3D数据采集利用迪克森梯度回声读取与 2D 图像导航器用于呼吸道门.
- 使用非刚性运动校正和基于低级补丁的方法重建图像; 通过字典匹配生成地图.
主要成果:
- 拟议的3D映射序列与幻影中的传统2D技术有很好的相关性.
- 在健康人群中,隔膜心肌组织的T1,T2和T2*值与2D参考值有很好的一致性.
- 当将拟议的映射与活跃心肌炎患者的2D参考进行比较时,观察到有希望的结果.
结论:
- 开发的方法允许在7分钟的扫描中同时进行3D全心关节T1/T2/T2*映射和水/脂肪成像.
- 该技术与幽灵和健康受试者的传统绘图方法有很好的一致性.
- 该方法对诊断心血管疾病具有前景,正如疑似心血管疾病患者的初步结果所表明的那样.
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