营养补充剂与运动相结合,与单独运动治疗膝关节骨关节炎:一项双盲,随机,安慰剂控制的试验
Wei Liu1, Yingxiang Yu1, Zhida Zhang1
1Department of Sports Medicine, Peking University Third Hospital, Institute of Sports Medicine of Peking University, Beijing, China.
Age and ageing
|February 21, 2025
概括
与炼相结合的配方营养补充剂与单独炼相比,显著改善了膝关节骨关节炎 (OA) 的结果. 这种综合方法在OA患者的疼痛和功能方面表现出早期和优异的改善.
科学领域:
- 整形外科和运动医学
- 营养科学 营养科学
- 类风湿病学 类风湿病学
背景情况:
- 膝关节骨关节炎 (OA) 是一种常见的退行性关节疾病,导致疼痛和功能限制.
- 目前的治疗侧重于疼痛管理和功能改善,运动是治疗的基石.
- 营养补充剂,特别是葡萄糖胺和冠状腺素,正在被研究其潜在的冠状腺保护和抗炎作用.
研究的目的:
- 为了评估配方营养补充剂 (葡萄糖胺硫酸盐,氏素硫酸盐,树根干细胞) 与监督运动相结合的疗效,与单独的运动相比,在治疗膝盖OA时.
- 为了比较对疼痛,硬,身体功能和下肢力量的影响.
主要方法:
- 一项为期6个月的双盲,随机,安慰剂对照试验,涉及65名膝关节OA的参与者 (40-75岁).
- 参与者被分配到营养补充剂加运动组 (N+E) 或安慰剂加运动组 (P+E).
- 主要结果:西部安大略省和麦克马斯特大学的骨关节炎指数 (WOMAC) 得分. 二次结果:身体功能,力量和血清生物标志物.
主要成果:
- 3个月后,N+E组在WOMAC总得分中获得临床重要差异最小值 (MCID) 的比率显著更高 (63.3%与30.8%,P<.01).
- 在6个月后,N+E组对WOMAC硬度的MCID率也更高 (63.3%对38.5%,P<.05) 和整体硬度降低更大.
- 在N+E组3个月后 (P<.05) 观察到下肢曲器峰值扭矩的显著改善.
结论:
- 配方营养补充剂与监督炼相结合,在膝关节OA治疗中比单独炼更有效.
- 这种综合方法导致疼痛,硬和身体功能更早,更明显地改善.
- 营养补充加上运动代表了更有效的治疗策略来管理膝关节OA.
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