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在母乳强化后,非常早产婴儿的肠道微生物群的发展
Lin Yang1, Yan Hui2, Per Torp Sangild1,3,4,5
1Section for Comparative Paediatrics and Nutrition, Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark.
mSystems
|February 21, 2025
概括
使用牛乳或常规强化剂为非常早产婴儿的母乳强化对肠道微生物群的影响最小. 出生方式暂时影响了婴儿的肠道微生物,但强化剂的选择对微生物社区结构的影响有限.
科学领域:
- 新生儿科学 新生儿科学
- 微生物学 微生物学
- 儿童营养学 儿童营养学
背景情况:
- 非常早产婴儿 (VPI) 的肠道不成熟,增加了对肠道失生症和诸如死性肠球炎等疾病的易感性.
- 人母乳强化对VPI至关重要,但最佳强化剂的选择仍然不清楚.
- 牛乳酪 (BC) 是传统强化剂 (CF) 的潜在替代品,因为它含有丰富的蛋白质和生物活性成分.
研究的目的:
- 调查牛乳粉 (BC) 与传统强化剂 (CF) 对非常早产婴儿 (VPI) 的肠道微生物群 (GM) 的影响.
- 评估出生方式对VPI中发育的GM的影响.
- 为了将转基因变化与临床结果如便pH值和体重增加相关联.
主要方法:
- 福蒂科洛斯研究 (NCT03537365) 涉及225名VPI,被养为BC或CF强化的母乳.
- 便样本在基线时使用16S rRNA基因安普利康序列分析,并在强化1周和2周后进行分析.
- 评估了肠道微生物组成,便pH值和体重增加.
主要成果:
- 出生方式显著影响了转基因结构的过渡性;剖腹产产的婴儿显示出Firmicutes的优势,而阴道产的婴儿有更多的蛋白质细菌.
- 强化型 (BC与CF) 对转基因结构的影响很小,在特定种群中没有显著差异.
- BC增加了便的pH值,与Staphylococcus和Corynebacterium正相关,与Bifidobacterium负相关;Staphylococcus丰度的变化与体重增加负相关.
结论:
- 用BC或CF强化母乳在生命早期对VPI肠道微生物群产生影响.
- 出生方式对VPI的发育肠道微生物群有显著但暂时的影响.
- 强化剂的选择对转基因结构的影响有限,允许临床专注于营养优化.
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