慢性鼻炎与鼻息肉 (CRSwNP) 的缓解
P W Hellings1, E De Corso2, V Backer3
1Allergy and Clinical Immunology Research Unit, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium;Clinical Department of Otorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, Leuven, Belgium;Upper Airways Research Laboratory, Department of Head and Skin, Ghent University, Belgium.
Rhinology
|February 21, 2025
概括
缓解是慢性鼻炎与鼻息肉 (CRSwNP) 的新目标. 实现这一目标意味着在没有口服类固醇或手术的情况下控制12个月的症状,这标志着CRSwNP管理的重大转变.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 过敏和免疫学 过敏和免疫学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 慢性鼻炎与鼻息肉 (CRSwNP) 的管理传统上集中在症状控制上.
- 尽管采用了传统疗法,但持续性症状往往仍然存在,因此需要新的治疗模式.
研究的目的:
- 引入和定义缓解作为CRSwNP护理的新目标.
- 要突出从症状控制到持续缓解状态的转变.
主要方法:
- 文献审查和专家建议的综合 (EUFOREA/EPOS).
- 对CRSwNP的缓解标准的定义:12个月的症状控制,没有口服皮质类固醇或内镜外科手术 (ESS),没有活跃的内镜疾病.
主要成果:
- 缓解被定义为疾病控制的长期状态.
- 这种状态至少需要12个月没有烦人的症状,口服皮质类固醇或ESS.
- 它还要求缺乏活跃疾病的内镜迹象.
结论:
- 缓解对于CRSwNP患者来说是一个更加雄心勃勃和可实现的目标.
- 包括生物制剂在内的新疗法有可能实现这种缓解状态.
- 耳鼻科社区和患者应将缓解作为CRSwNP护理的主要目标.
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