在英国生物库中,年龄是否会改变对玻璃眼的遗传倾向和各种玻璃眼特征之间的关系?
Jihye Kim1, Jae H Kang2, Janey L Wiggs3
1Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States.
Investigative ophthalmology & visual science
|February 21, 2025
概括
随着年龄的增长,玻璃眼多基因风险评分成为高眼内压和玻璃眼的更强有力的预测因素. 年龄和遗传数据对于有效的玻璃眼查策略至关重要.
科学领域:
- 眼科医生 眼科 眼科
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 玻璃眼是全球不可逆转的失明的主要原因.
- 多基因风险评分 (PRS) 为复杂疾病的个性化风险预测提供了一个有希望的途径.
- 了解遗传倾向如何与年龄等人口因素相互作用,对于优化查策略至关重要.
研究的目的:
- 为了研究年龄对多特征光眼多基因风险评分 (mtGPRS) 的预测能力的影响.
- 评估mtGPRS与关键初级开角青光眼的主要指标之间的关系:眼内压力 (IOP),视网膜结构和青光眼的患病率.
- 为了确定将年龄与遗传信息整合为格洛科马公共卫生查的有用性.
主要方法:
- 分析英国生物库参与者 (n=192,283) 的人口和遗传数据.
- 使用2673个遗传变异构建一个mtGPRS.
- 多变量回归模型评估年龄-mtGPRS对IOP的相互作用,黄斑视网膜神经纤维层厚度 (mRNFL),黄斑结节细胞内状层厚度 (mGCIPL) 和青光眼的患病率,调整为混因素.
主要成果:
- 年龄显著改变了mtGPRS和IOP之间的关联 (Pinteraction = 2.7e-27),在老年四分位数中关联更强.
- 类似的年龄依赖的趋势也被观察到在青光眼的患病率上 (Pinteraction = 1.0e-06).
- mtGPRS和内视网膜厚度 (mRNFL,mGCIPL) 之间的关系因年龄而有不一致的改变.
结论:
- 对于眼内压和青光眼的患病率,mtGPRS的预测值随着年龄的增长而增加.
- 将时间表年龄与遗传风险信息相结合,可以提高针对性玻璃眼查计划的设计.
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