生命的基本8和早发性心血管疾病的成年人死亡率:一个前性的社区研究
Jing Yang1, Xiao Chen2, Yaqi Li2
1Department of Cardiology, Tangshan Gongren Hospital, No.27, Wenhua Road, Lubei District, Tangshan, 063000, Hebei Province, China.
Herz
|February 21, 2025
概括
使用Life's Essential 8 (LE8) 指标改善心血管健康 (CVH) 与早发性心血管疾病 (CVD) 的成年人全因死亡率降低有关. 较高的LE8分数表明更好的CVH和降低死亡风险.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 预防医学 预防医学
背景情况:
- 有限的数据存在心血管健康 (CVH) 评估的生命的基本8 (LE8) 和其与所有原因死亡率的关联在早期发作的心血管疾病 (CVDs).
- 早期出现的心血管疾病对健康造成重大负担,需要对可修改的风险因素和死亡预测因素进行研究.
研究的目的:
- 评估通过LE8指标测量的CVH与中国成年早期患有心血管疾病的全因死亡率之间的关联.
- 研究CVH对各种早期CVD亚型的死亡率的影响,包括心肌梗塞,心力衰竭,心房动和中风.
主要方法:
- 从Kailuan研究 (2006-2020) 中分析了3454名被诊断患有早期心血管疾病的参与者 (男性<55岁,女性<65岁).
- 使用LE8指标 (饮食,体力活动,尼古丁暴露,睡眠,BMI,脂质,葡萄糖,血压) 评估CVH,得分从0到100不等.
- 考克斯比例危险回归和受限立方线被用来分析CVH得分与全因死亡率之间的关联.
主要成果:
- 在平均6.78年的随访期间,共有460人死亡.
- 较高的CVH得分与早期出现心血管疾病的个体全因死亡风险降低显著相关 (HR为每10个点的0.85,p趋势=0.001).
- 在出血性中风 (HR 0.46) 和心脏病 (HR 0.59) 中发现了显著的反向关联.
结论:
- 基于LE8指标的较高心血管健康得分,与早期出现心血管疾病的成年人全因死亡率的有益影响有关.
- 促进和改善心血管健康对于降低被诊断患有心血管疾病的年轻人死亡风险至关重要.
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