在自闭症儿童和成人中休息时的自主失衡
Maria Rosa Bufo1,2, Marco Guidotti1,3,4, Mathieu Lemaire1,3
1Université de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253, 37032, Tours, France.
Applied psychophysiology and biofeedback
|February 21, 2025
概括
自闭症谱系障碍 (ASD) 与自主神经系统 (ANS) 的差异有关. 自闭症儿童表现出偏交感的低活化,而自闭症成年人表现出改变的交感活动,表明发育变化.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 自主生理学 自主生理学
背景情况:
- 自主神经系统 (ANS) 功能障碍,特别是交感性过度兴奋和副交感性低激活,是自闭症谱系障碍 (ASD) 的假设.
- 了解ASD在整个发育过程中的自主功能对于确定潜在的治疗点至关重要.
研究的目的:
- 描述自闭症和神经类型儿童和成人休息时的自主功能.
- 调查自闭症人口中自主模式的年龄相关差异.
主要方法:
- 在5分钟的休息状态中同时记录瞳孔直径,心率和皮肤活动.
- 对交感和副交感活动的强力和相位指数的分析.
- 包括44名儿童 (6-12岁) 和42名成年人 (19-52岁),在每个年龄组中包含自闭症和神经类型组.
主要成果:
- 与神经类型同龄人相比,自闭症儿童表现出偏交感的低激活和更高相性交感活动的趋势.
- 自闭症成年人表现出相反的模式:比神经类型的成年人更高的交感音调和更低的交感相活动.
- 这些发现表明在自闭症儿童和成年人中存在休息时的自主失衡,其模式是不同的.
结论:
- 自主功能在自闭症中呈现出儿童与成人的相反模式,表明成熟变化和适应性补偿机制.
- 在自闭症的发展过程中,观察到的从相性到强力交感主导的转变可能涉及非典型的状元功能.
- 自主性失调是整个生命周期中自闭症的一个重要特征,发育轨迹影响其表现.
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