在儿科炎性肠病中的红细胞甲基甲酸-多氨酸度
Eva Vermeer1,2,3, Eduard A Struys4, Marry Lin4
1Department of Paediatric Gastroenterology, Emma Children's Hospital, Amsterdam University Medical Centre, Amsterdam, The Netherlands.
红细胞甲基酸多重胺酸 (MTX-PG) 显示出治疗药物监测 (TDM) 在儿科炎性肠病 (IBD) 中的前景. 更高的MTX剂量与MTX-PG水平的增加相关,支持它们在TDM中的使用.
科学领域:
- 药理学 药理学 是一个学科.
- 儿科胃肠病学 儿科胃肠病学
- 分析化学 分析化学
背景情况:
- 甲状腺素 (MTX) 的治疗药物监测 (TDM) 由于其药理动力学而具有挑战性.
- 细胞内MTX多重胺酸 (MTX-PG) 尚未在儿科炎症性肠病 (IBD) 中进行评估.
研究的目的:
- 评估红细胞MTX-PG作为在儿科IBD中潜在的TDM工具.
- 评估MTX剂量,注射途径和人体测量对MTX-PG度的影响.
主要方法:
- 78名IBD儿童接受稳定低剂量MTX的横截面研究.
- 使用稳定同位素稀释液体染色学-并联质谱法测量红细胞MTX-PG度.
- 检查了MTX剂量,服用途径,人体测量和MTX-PG水平之间的相关性.
主要成果:
- MTX-PG3是占主导地位的亚种,MTX-PG总中位数为74.8nmol/L.
- 较高的MTX剂量与MTX-PG3,MTX-PG4,MTX-PG5和MTX-PG总量的增加有显著的相关性 (P < .01).
- 在调整身体表面积 (P < .01) 后,MTX剂量仍然与较高的MTX-PG度显著相关.
结论:
- 红细胞MTX-PG度的高个体间变异性被观察到.
- 在儿科IBD中,MTX剂量与红细胞MTX-PG度呈正线性相关性.
- 红细胞MTX-PG度是TDM的先决条件,支持对MTX有效性和毒性的进一步研究.
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