对于持续的甲状腺功能低下症状,LT4/LT3组合治疗的长期结果
European thyroid journal
|February 21, 2025
概括
甲状腺功能低下症的Levothyroxine/liothyronine (LT4/LT3) 组合疗法耐受性良好,生活质量 (QoL) 高. 然而,许多患者仍然经历持续的甲状腺功能低下症状,尽管治疗.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 患者越来越多地要求Levothyroxine/Liothyronine (LT4/LT3) 组合治疗持续的甲状腺功能低下症状.
- 治疗LT4/LT3的长期疗效和副作用尚未得到充分证实.
研究的目的:
- 要描述经历长期LT4/LT3治疗的患者组.
- 评估这些患者的生活质量 (QoL) 和甲状腺功能低下症状.
主要方法:
- 66名接受LT4/LT3治疗的甲状腺功能低下患者的横截面研究.
- 患者被分为LT4/LT3响应者和LT3不响应者.
- 使用ThyPRO评估生活质量;用验证得分评估甲状腺功能低下症状.
主要成果:
- 平均年龄56岁;治疗开始前5.4年.
- 54名患者继续接受LT4/LT3;由于缺乏效果,12名患者中止了治疗.
- LT4/LT3响应者具有与一般人群相似的QoL,但症状得分高,类似于明显的甲状腺功能低下症.
- 38%的LT4/LT3响应者抑制了TSH (<0.4 mU/L),这表明过度治疗.
结论:
- 治疗LT4/LT3的耐受性很好,高的QoL和没有报告的副作用.
- 尽管治疗和高的QOL,患者继续出现显著的甲状腺功能低下症状.
- 潜在的过度治疗被大量患者的TSH水平抑制所表明.
相关概念视频
Synthesis and Regulation of Thyroid Hormones
4.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.1K
Pulmonary Tuberculosis V
166
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
166
Functions of Thyroid Hormones
2.5K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.5K
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
510
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
510
Diabetes: Management and Pharmacotherapy
227
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
227
Drug Therapy
34
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
34


