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Updated: May 26, 2025

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
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通过mRNA稳定蛋白TTP抑制由炎酶驱动的细胞因子反应

Meghan E O'Keefe1, Hannah C Kondolf1, Stefania De Santis1

  • 1Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

Cell reports
|February 21, 2025
PubMed
概括

激活NLRP3炎症酶会破坏细胞平衡,并抑制ERK1/2信号传递. 这导致tristetraprolin (TTP) 活性降低,增加细胞因子的释放,并可能恶化炎症性疾病.

关键词:
CP: 免疫学 免疫学科普:分子生物学 分子生物学在MAP基因酶中,MAP基因酶是最重要的.细胞因子 细胞因子一些炎症一些炎症线粒体中的线粒体.酸酶是一种酸酶.翻译后的修改 翻译后的修改信号布是一系列的信号.

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