门诊患者中的COVID-19症状严重程度和持续时间,2021年7月至2023年5月:PROTECT观察性研究
Bhavya Vashi1, Kristen Pettrone1, Claire S Wilson2
1The Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO), The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland, United States of America.
PloS one
|February 21, 2025
概括
COVID-19 症状的持续时间和严重程度因变种而异,Omicron 导致的疾病时间比 Delta 病毒更短. 在门诊患者中发现的严重症状的危险因素很少,尽管男性性别与症状持续时间较短相关.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 新出现的SARS-CoV-2变种在非住院患者中引起各种疾病表现.
- 了解症状模式和风险因素对于管理COVID-19和类似流感的疾病至关重要.
研究的目的:
- 描述症状模式,并确定COVID-19和ILI门诊患者症状严重程度和持续时间的危险因素.
- 为了比较COVID-19变种 (Delta和Omicron) 和ILI之间的症状体验.
主要方法:
- 确认的COVID-19和ILI病例,以及健康的接触者,在多个地点注册.
- 收集了人口统计,病史和每日自我报告的症状数据.
- 多变量逻辑回归和考克斯比例危险模型分析了症状严重程度和持续时间的风险因素.
主要成果:
- 分析了174例COVID-19病例 (9%Delta,90%Omicron) 和33例ILI病例. 这些病例包括:
- 与ILI患者相比,COVID-19患者的症状持续时间中位数较短 (9.0天).
- 德尔塔变种感染导致症状持续时间比Omicron更长;德尔塔病例报告了更多的症状,特别是影响眼睛和感官. 男性的性别与较短的症状持续时间有关. 没有发现中度至重度症状的显著风险因素.
结论:
- 在SARS-CoV-2 Delta和Omicron变种之间,症状呈现有显著差异.
- 在这种门诊队列中,仅确定了增加症状严重程度或持续时间的有限风险因素.
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