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Updated: May 26, 2025

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在人体细胞中,ZBP1驱动的亡需要RIPK1

Oluwamuyiwa T Amusan1, Shuqi Wang1, Chaoran Yin2

  • 1Department of Microbiology and Immunology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, Louisiana, United States of America.

PLoS biology
|February 21, 2025
PubMed
概括

主体传感器的Z-结合蛋白1 (ZBP1) 触发了病毒防御的亡. 人类细胞需要RIPK1来形成ZBP1-RIPK3复合体,与小鼠不同,揭示了亡的关键物种特异性差异.

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