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Updated: May 26, 2025

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
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Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Published on: August 21, 2017

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在光学神经炎中,aquaporin-4自身抗体结合的结构基础

Meghna Gupta1,2, Nitesh Kumar Khandelwal1,2, Andrew Nelson1

  • 1Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143, USA.

Science advances
|February 21, 2025
PubMed
概括

光学神经炎 (NMO) 是一种针对水素-4的自身免疫性疾病. Cryo-EM揭示了NMO自身抗体如何与aquaporin-4结构结合,从而提供了对疾病机制的见解.

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Antibody Structure01:10

Antibody Structure

Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
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