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对POSEIDON患者的第三天转移策略的分析

Jakub Wyroba^1,2, Joanna Kochan^1,3

¹Malopolski Institute of Fertility Diagnostics and Treatment - krakOvi, Krakow, Poland.

JBRA assisted reproduction

|February 21, 2025

概括

第三天胚胎移植 (ET) 策略对POSEIDON患者仍然有效,结果因POSEIDON组而异. 第一组提供最好的预后,而第四组在生育治疗方面最差.

科学领域:

生殖医学生殖医学
胚胎学胚胎学
在体外受精过程中受精.

背景情况:

该POSEIDON (植入前遗传查和诊断) 分类识别了卵巢储量减少或IVF结果差的患者.
优化胚胎移植 (ET) 时间和策略对于提高试管婴儿成功率至关重要,特别是在具有挑战性的患者群体中.

研究的目的:

在POSEIDON和非POSEIDON患者组中评估第3天胚胎移植策略的有效性.
为了比较3日转移的胚胎的形态特征和植入潜力,在这些患者队伍之间进行移植.

主要方法:

对600个POSEIDON和600个非POSEIDON试管婴儿周期进行分析,以确定ET时间 (3日,5日或冷胚胎移植[FET]).
对330天3ET的审查,以评估胚胎发育阶段,形态, zona pellucida厚度和植入潜力.

主要成果:

波赛顿患者主要使用第3天ET (42%) 或取消周期 (37%),而非波赛顿患者偏好FET (44%).
在POSEIDON III和IV组中观察到较低的胚胎发育率. 高质量的胚胎 (A级) 在POSEIDON组I (47%) 中最常见.
在非POSEIDON<35Y (28%) 和POSEIDON I (28%) 和III (26%) 组中,发现植入潜力最高. 在所有组中,年龄≥35岁的患者中都观察到流产率的增加.

结论:

对POSEIDON患者来说,3日ET策略似乎是最佳的,预后与他们的特定POSEIDON组密切相关.
波赛顿I组表现出最有利的结果,而IV组在试管婴儿成功方面呈现出最不有利的预后.

关键词:

在此之前,他曾经在一家公司工作过,但现在他已经在一家公司工作了.ET第3天的第3天美国国务院调查局 (ICSI)波赛顿 (POSEIDON) 是一个这些胚胎是胚胎.低响应者是低响应者

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