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在Bacillus Calmette-Guerin治疗膀癌后的胆红素炎

Nithya Boopathiraj¹, Isabella V Wagner¹, Ross Powers²

¹Department of Ophthalmology, Mayo Clinic, Jacksonville, Florida.

Retinal cases & brief reports

|February 21, 2025

概括

在治疗膀癌的Bacillus Calmette-Guerin (BCG) 治疗后11个月,发生了一种罕见的真菌细菌性胆炎病例. 迅速治疗导致眼部病变的完全回归,强调了考虑这种并发症的重要性.

科学领域:

眼科医生眼科眼科
传染性疾病传染性疾病
在瘤学瘤学.

背景情况:

静脉内巴塞勒斯卡尔梅特 - 格林 (BCG) 是膀癌的标准治疗方法.
BCG疗法很少会导致系统性并发症.
在BCG治疗的眼部表现不常见.

研究的目的:

为了呈现一种罕见的多焦点胆管网膜炎病例.
为了突出膀癌的静脉BCG治疗后的潜在并发症.

主要方法:

一份病例报告,详细介绍患者的表现和治疗.
利用下一代测序 (卡里乌斯测试) 来检测微生物无细胞DNA.
光学连贯性断层扫描 (OCT) 用于成像视网膜和胸膜干扰.

主要成果:

一名74岁的男性在BCG治疗后11个月出现视觉变化和体质症状.
眼部检查显示多焦点胆管关节病变.
下一代测序发现了Mycobacterium结核复合体;三重治疗导致了完整的病变回归.

结论:

菌根性胆红素炎是一种罕见的,但在静脉BCG治疗后可能出现的并发症.
对于BCG后出现视觉症状的患者来说,考虑这种诊断至关重要.
早期诊断和治疗对于有利的视觉结果至关重要.

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