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Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
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钻石纳米针用于生物感知.

Mariam Quarshie1, Lena Golubewa2,3, Caterina Giraulo4

  • 1Department of Physics and Mathematics, University of Eastern Finland, Joensuu, Finland.

Nanotechnology
|February 21, 2025
PubMed
概括
此摘要是机器生成的。

单晶钻石纳米针 (SCDNNs) 显示出医学应用的潜力. 这些生物相容纳米颗粒无细胞毒性,可用于生物成像和药物输送.

关键词:
在SiV−中心.生物医学应用程序钻石针钻石针的使用方法摄影光的发光效应

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科学领域:

  • 纳米医学是一种纳米医学.
  • 生物技术是生物技术.
  • 材料科学 材料科学 材料科学

背景情况:

  • 纳米粒子和纳米材料提供了多样化的医疗应用,包括诊断和治疗.
  • 了解纳米物体与生物细胞的相互作用对于实现它们的全部潜力至关重要.

研究的目的:

  • 研究单晶钻石纳米针 (SCDNNs) 与生物物质的相互作用.
  • 评估人类肺纤维细胞对SCDNN的细胞反应.

主要方法:

  • 微光发光 (PL) 绘制地图
  • 同焦点显微镜的共聚焦显微镜
  • 乳酸脱酶 (LDH) 活力测试

主要成果:

  • SCDNN和细胞可以并存,有效地注册空位 (SiV-) 颜色中心.
  • 最小的LDH释放表明,在2-32μg ml-1.0的度下,最佳尺寸的SCDNN具有非细胞毒性.

结论:

  • 在表面修饰后,SCDNN显示出在细胞外和/或细胞内药物递送的潜力.
  • 在SCDNN中的光缺陷可以用于生物成像和光学/量子传感.