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在中,热应激会诱导体微生物群的时间变化,并与宿主肠道的血清激素反应并发
Joshua M Lyte1, Xinglin Jia2, Valentina Caputi1
1Poultry Production and Product Safety Research Unit, Agricultural Research Service, United States Department of Agriculture, Fayetteville, AR 72701, USA.
Poultry science
|February 21, 2025
概括
热应激会影响肠的血清素和微生物组. 急性热量会降低血清素,而慢性热量会增加血清素,改变有益的细菌,如乳酸菌和双菌.
科学领域:
- 鸟类生理学 鸟类生理学
- 微生物组研究的研究.
- 神经内分泌学神经内分泌学
背景情况:
- 热应激显著影响鸟类的神经内分泌系统和肠道微生物群.
- 血清素是一种跨王国信号分子,在鸟类肠道光线中很丰富.
- 热应激对鸟类肠道血清度和微生物群的影响尚不清楚.
研究的目的:
- 为了研究急性和慢性热应激如何影响的肠道血清度.
- 为了确定热应激对肠微生物组的组成和功能的影响.
- 探索热应激,血清激素水平和家禽肠道微生物组之间的关系.
主要方法:
- 暴露于急性 (1天),重复急性 (2天) 或慢性 (6天) 中等周期性热应激 (12小时/天31°C).
- 测量了肠道血清激素度.
- 枪支元基因组测序被用来分析的微生物组.
主要成果:
- 肠道血清度在急性热应激后显著下降,但在慢性热应激后增加.
- 热应激诱导了Cecal微生物群的显著功能和分类学变化.
- 关键细菌种群的丰富性,包括乳杆菌 spp. 和Bifidobacterium spp., 已知与血清激素系统相互作用,被显著改变.
结论:
- 热应激会以持续时间依赖的方式改变的肠道血清度.
- 血清能信号传递代表了调节宿主微生物相互作用和病原体殖民化的潜在干预点.
- 这项研究为急性和慢性热应激如何影响鸟类微生物组及其与肠道血清系统的联系提供了新的见解.
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