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Updated: Jul 24, 2026

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients
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通过UHPLC-MS/MS在人体血中的万科米辛的高吞吐量分析

Xiaoqian Chen1, Luyao Yu2, Yingxia Guo2

  • 1Central Hospital of Dalian University of Technology, Dalian University of Technology, Dalian, Liaoning 116023, PR China; Department of Pharmacology, College of Pharmacy, Dalian Medical University, Dalian, Liaoning, 116044, PR China.

Journal of pharmaceutical and biomedical analysis
|February 21, 2025
PubMed
概括

一种新的超高性能液态染色学-并联质谱法 (UHPLC-MS/MS) 试验准确量化了生物样本中的万科米辛. 这种方法具有选择性,精确性,适合治疗药物监测.

关键词:
确定性的决定微固态相提取微固态相提取方法治疗药物监测 治疗药物监测在UHPLC-MS/MS中使用.范科米辛是一种药物.

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相关概念视频

High-Resolution Mass Spectrometry (HRMS)01:15

High-Resolution Mass Spectrometry (HRMS)

The resolution of a mass spectrometer depends on the efficiency of separating ions with different ion masses. The mass of an atom is approximated to the sum of the masses of protons and neutrons inside, considering the masses of protons and neutrons as equal. However, the masses of the proton (1.6726 × 10−24 g) and neutron (1.6749 × 10−24 g) are not truly equal. There is a minor error in the expression of atomic masses relative to the simplest atom of hydrogen. For example, the mass of helium...