黑色素通过调节p38信号通路来改善Pb诱导的线粒体平衡和卵巢损伤
Zhuo-Nan Yang1, Xin Du2, An Wang3
1Reproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China; NHC Key Laboratory of study on abnormal gametes and reproductive tract, Anhui Medical University, Hefei 230022, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University),Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei, Anhui 230032, China; Anhui Province Key Laboratory of Reproductive Disorders and Obstetrics and Gynaecology Diseases, No 81 Meishan Road, Hefei, Anhui 230032, China; Biopreservation and Artificial Organs, Anhui Provincial Engineering Research Center, Anhui Medical University, No 81 Meishan Road, Hefei, Anhui 230032, China.
暴露于会损害女性的生殖和卵巢储备. 黑色素 (MT) 通过恢复线粒体功能和调节P38信号通路来防止毒性,为减少卵巢储备 (DOR) 提供了潜在的治疗策略.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 环境毒理学环境毒理学
- 线粒体生物学 线粒体生物学
背景情况:
- (Pb) 是一种普遍存在的环境污染物,已知对女性生殖健康有不良影响.
- 卵巢储备减少 (DOR) 是一个越来越令人担忧的问题,它与重金属暴露的联系需要进一步调查.
- 氨酸 (MT) 是一种抗氧化剂,具有减轻重金属毒性的潜力,但其在引起的卵巢功能障碍中的具体作用尚不清楚.
研究的目的:
- 为了研究患者血液中含量和卵巢储备减少 (DOR) 之间的关系.
- 在小鼠模型中阐明暴露对卵巢卵泡发育的影响.
- 确定黑色素 (MT) 对诱导的卵巢毒性的保护机制.
主要方法:
- 在DOR患者和对照人群中测量血水平.
- 暴露于C57BL6雌性小鼠的酸三水合物和评估的卵泡发育,亡和自.
- 评估了黑激素 (MT) 联合治疗对诱导的卵巢功能障碍的影响,包括AMH水平,线粒体平衡和P38信号通路酸化.
主要成果:
- 与对照组相比,在DOR患者中观察到血水平升高.
- 在没有显著的亡或过度自的小鼠中,暴露诱导了异常的毛囊发育.
- 黑色素 (MT) 治疗逆转了引起的AMH水平下降,恢复了线粒体平衡 (平衡融合/裂变蛋白),并挽救了P38通路酸化.
结论:
- 暴露对线粒体平衡和卵巢储备功能的负面影响.
- 黑色素 (MT) 通过恢复线粒体平衡和调节P38信号通路,有效地防止诱导的卵巢毒性.
- 用黑激素 (MT) 准P38信号通路是导致暴露的卵巢储备减少 (DOR) 的有希望的治疗策略.
相关概念视频
Hormonal Regulation of the Menstrual Cycle
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
Menopause
Oogenesis
Hormonal Control of the Ovarian Cycle
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Management of Insomnia


