风湿性关节炎患者与间歇性肺部疾病的肠道微生物群的变化:一项比较研究
Xue Zhong1, Xiaohong Wang1, Lulu Xu1
1Department of Gerontology, Chongqing General Hospital, Chongqing University, PR China.
Human immunology
|February 21, 2025
概括
与类风湿性关节炎患者和健康人群相比,与类风湿性关节炎相关的间歇性肺病 (RA-ILD) 患者表现出不同的肠道微生物群概况. 这些微生物差异可能为RA-ILD提供新的治疗点.
科学领域:
- 微生物组研究的研究.
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
背景情况:
- 类风湿关节炎相关的间歇性肺病 (RA-ILD) 是类风湿关节炎 (RA) 的严重并发症.
- 人们越来越认识到肠道微生物群在自身免疫性疾病中的作用,但其在RA-ILD中的具体参与仍未得到充分研究.
- 了解RA-ILD中的肠道微生物群对于阐明疾病发病因子至关重要.
研究的目的:
- 为了研究和比较RA-ILD患者的肠道微生物组成,没有ILD的RA,和健康的对照.
- 为了确定与RA-ILD相关的特定微生物变化.
- 探索肠道失调和RA-ILD发展之间的潜在联系.
主要方法:
- 从三个组收集便样本:RA-ILD患者 (n=30),没有ILD的RA患者 (n=31) 和健康对照 (n=30).
- 使用16S rRNA基因测序来分析微生物多样性和组成.
- 统计分析包括多样性评估 (α和β),主要坐标分析 (PCoA) 和差异丰度测试 (LEfSe,PICRUSt2).
主要成果:
- 在RA-ILD患者与其他两组之间,发现了肠道微生物群组成的显著差异.
- 普雷沃特拉属的丰度差异很大,特别是在RA-ILD患者中.
- 在RA-ILD患者中,KEGG途径分析表明了显著的微生物代谢活性,与RA和对照组相比,几个途径上调.
结论:
- 与没有ILD和健康对照的RA患者相比,RA-ILD患者具有显著改变的肠道微生物群概况.
- 这些微生物转移可能在RA-ILD的发病过程中发挥作用.
- 鉴定到的肠道微生物群变化代表了RA-ILD的潜在生物标志物和治疗点,需要对其临床影响进行进一步调查.
更多相关视频
相关概念视频
01:17Chronic Bowel Disorders: Introduction
378
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
378
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
295
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
295
01:17Irritable Bowel Syndrome I: Introduction
219
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
219
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
114
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
114
01:30Inflammatory Bowel Disease II: Crohn's Disease
158
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
158
01:23Anatomy of the Intestines
71.2K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.2K