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氨酸干预诱导PD-L1表达,以增强MTAP删除骨髓瘤的免疫检查点治疗反应

Haoran Mu1, Qi Zhang2, Dongqing Zuo1

  • 1Department of Orthopedic Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Bone Tumor Institution, Shanghai, China.

Cell reports. Medicine
|February 21, 2025
PubMed
概括

带有MTAP删除的骨髓瘤抵抗免疫疗法. 在临床前模型中,通过改变新陈代谢,氨酸干预增强了免疫反应和ICT疗效.

关键词:
在 IKZF1这就是 MAT2A.删除MTAP的删除方法在PD-L1中.免疫疗法 免疫疗法甲氨酸的新陈代谢骨质肉瘤是骨质肉瘤的一种疾病.瘤微环境是一个微环境.

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