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Updated: May 26, 2025

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一个核体开关原始的乙型肝炎病毒感染

Nicholas A Prescott1, Tracy Biaco2, Andrés Mansisidor3

  • 1Tri-Institutional PhD Program in Chemical Biology, New York, NY 10065, USA; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Cell
|February 21, 2025
PubMed
概括

慢性乙型肝炎病毒 (HBV) 感染涉及病毒DNA (cccDNA) 形成一个小染色体. 这种ccDNA的核细胞占用调节病毒X基因转录,为HBV提供潜在的治疗点.

关键词:
染色体表观遗传学乙型肝炎病毒核细胞稳定性转录

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The Nucleosome Core Particle01:12

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Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
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