精神分裂症,双相情感障碍和严重抑郁症可能不是心血管疾病的危险因素:孟德尔的随机研究
Jin Chen1, Wenhuan Duan2, Peizi Liu2
1Department of Geriatric Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, China; Department of Psychiatry, The Affiliated Xuzhou Eastern Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221004, China.
Journal of affective disorders
|February 21, 2025
概括
这项研究使用了门德尔的随机化来调查严重精神疾病 (SMI) 和心血管疾病 (CVD). 没有发现因果关系,这表明SMI可能是CVD的风险标志物,而不是确定因素.
科学领域:
- 遗传学 遗传学 是一个
- 精神病学是一个精神病学.
- 心脏病学 心脏病学
背景情况:
- 患有严重精神疾病 (SMI) 的个人,包括精神分裂症,双相情感障碍 (BD) 和严重抑郁障碍 (MDD),面临心血管疾病 (CVD) 的更高风险.
- 目前尚不清楚SMI和CVD之间的确切因果关系,需要进一步调查.
研究的目的:
- 调查SMI和CVD之间的潜在因果关系,包括五种亚型:冠心病,心肌梗塞,中风,心力衰竭和心房动.
- 评估身体质量指数 (BMI) 在BD和CVD之间的调解作用.
主要方法:
- 门德尔随机化 (MR) 分析,包括单变量 (UVMR) 和多变量 (MVMR) 方法,使用单核酸多态 (SNP) 进行.
- 进行了对MR结果的元分析和MR中介分析,以评估关联和BMI的中介作用.
- 通过使用科克兰的Q测试,MR-Egger拦截测试,MR-PRESSO和留出一个漏洞分析来评估强度.
主要成果:
- 在一些数据集中,MR分析表明精神分裂症和BD与心血管疾病及其亚型之间的相关性.
- 在MDD和CVD或其亚型之间没有发现显著的关联.
- 在MVMR和元分析之后,没有证据支持SMI和CVD之间的遗传预测因果关系;然而,BMI部分介导了BD中某些CVD的风险降低.
结论:
- 该MR研究没有确定SMI和CVD的遗传倾向之间的确的因果关系.
- 目前的证据表明,SMI应该被视为潜在的风险标志物,而不是对心血管疾病及其亚型的最终风险因素.
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