六种自身免疫性疾病和恶性瘤之间的风险关系:一个总体审查
Ping Yang1, Qinguo Liu2, Hengheng Zhang1
1Qinghai University, China; The Center of Breast Disease Diagnosis and Treatment of Affiliated Hospital of Qinghai University & Affiliated Cancer Hospital of Qinghai University, Xining 810000, China.
Autoimmunity reviews
|February 21, 2025
概括
五种自身免疫性疾病增加了整体癌症风险,而多发性硬化症 (MS) 降低了癌症风险. 特定的癌症风险因自身免疫性疾病而异,影响长期患者管理策略.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 自身免疫性疾病和癌症风险之间的联系是复杂的,并且有很大的差异.
- 了解这些关联对于个性化患者管理和癌症预防至关重要.
研究的目的:
- 系统地重新分析六种特定的自身免疫性疾病与恶性瘤风险之间的关联现有证据.
- 为优化自身免疫性疾病患者的长期癌症风险管理提供见解.
主要方法:
- 在PubMed,Web of Science和Cochrane图书馆进行了系统的文献搜索.
- 34个元分析,包括742个个别研究,被纳入重新分析.
主要成果:
- 系统性红斑狼 (SLE),类风湿性关节炎 (RA),牛皮 (PsO),关节炎 (AS) 和初级斯乔格伦综合征 (pSS) 与总体恶性瘤风险的增加有关.
- 多发性硬化症 (MS) 与整体恶性瘤风险降低有关.
- 具体的癌症风险因自身免疫性疾病而异;例如,SLE患者患淋巴瘤的风险更高,而AS患者患淋巴细胞白血病的风险更高.
结论:
- 五种自身免疫性疾病 (SLE,RA,PsO,AS,pSS) 增加了整体恶性瘤的风险.
- 多发性硬化症 (MS) 与整体恶性瘤风险降低有关.
- 特定的自身免疫性疾病与不同类型的癌症之间的关系是细微的,需要个性化评估.
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