一个以波浪为中心的损伤模型,用于原软组织
Jia Lu1, Xuehuan He1, Ferdinando Auricchio2
1Department of Mechanical Engineering, The University of Iowa, Iowa City, IA 52242, USA.
Acta biomaterialia
|February 21, 2025
概括
这项研究引入了对原组织的新损伤模型,解释了纤维波动如何影响负载下的组织反应. 该模型准确地预测了组织损伤的进展,这对于理解生物机械行为至关重要.
科学领域:
- 生物力学 生物力学
- 生物材料科学 生物材料科学
- 组织工程是组织工程.
背景情况:
- 原组织在单调负荷下表现出复杂的非线性行为.
- 纤维波动性显著影响这些组织中的机械反应和损伤启动.
- 现有的模型可能无法完全捕捉纤维招募和损伤进展之间的相互作用.
研究的目的:
- 开发和验证一种新的损伤模型,用于在单调负荷下对原组织的损伤.
- 阐明原纤维波动性在组织损伤的开始和进展中的作用.
- 为血管组织的生物力学行为提供预测工具.
主要方法:
- 假设损伤开始在更直,更拉伸的原纤维中,进展到波浪纤维.
- 将复杂的非线性反应建模为纤维招募和纤维损伤之间的平衡.
- 在波动域内实施一个不断变化的损害阵线,由功率定律支配.
- 拟议模型与已发表的血管组织的单轴和双轴试验数据相匹配.
主要成果:
- 该模型成功地捕捉了完整纤维招募和损坏纤维损失的竞争机制.
- 波动域中的不断演变的损伤前线有效地描述了损伤的进展.
- 对于损坏前线演变的拟议动力法证明了与实验数据的良好一致.
- 现场实现的模型适合四个不同的血管组织测试数据集.
结论:
- 开发的损伤模型准确地反映了原组织在单调负荷下的行为.
- 原纤维波动性是决定损伤开始和进展的关键因素.
- 该模型为预测血管组织的机械反应和失效提供了一个强大的框架.
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