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电子与质子FLASH辐射对小鼠皮肤毒性的影响

Line Kristensen¹, Sky Rohrer², Lone Hoffmann³

¹Danish Centre for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark; Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

|February 21, 2025

概括

快速,高剂量电子辐射 (FLASH) 在小鼠中显示出一种与质子FLASH相似的皮肤节约效应. 这项研究量化了电子FLASH的剂量修改因子,将急性皮肤和晚期纤维性毒性与传统辐射进行比较.

科学领域:

辐射瘤学辐射瘤学
医学物理医学物理
临床前研究临床前研究

背景情况:

快速,高剂量率 (FLASH) 辐射疗法证明了对急性毒性的剂量节约效应.
之前的研究证实了质子FLASH的这种效应,但对于急性和晚期效应的电子FLASH数据都缺乏.

研究的目的:

在小鼠中量化电子FLASH辐射对急性皮肤和晚期纤维性毒性的剂量反应改变.
为了能够对电子和质子FLASH之间的急性皮肤反应进行定量比较.

主要方法:

雌性C3D2F1小鼠在常规 (CONV,0.162 Gy/s) 或FLASH (233 Gy/s) 剂量速率下接受了水平电子辐射 (16 MeV).
小鼠接受了从19.4-57.6 Gy的单剂量,每组有8-10只小鼠.
每天评估28天的急性皮肤毒性;通过腿部延长至52周评估晚期纤维性毒性.

主要成果:

电子闪光显示出显著的皮肤节约作用,剂量修饰因子 (DMF) 为1.45-1.54.
观察到较小的纤维节约效应,晚期毒性的DMF为1.15.
在使用基于DMF的生物等效剂量时,CONV和FLASH组之间的急性皮肤毒性发展是可比的.

结论:

电子FLASH提供了相当大的皮肤节约效果,与质子FLASH相美.
对电子FLASH的急性皮肤毒性反应与之前报告的质子FLASH数据相似.
在临床前模型中,FLASH辐射显示了减少辐射诱导毒性的潜力.

关键词:

急性损伤是一种急性损伤.电子辐射辐射的电子辐射.一个闪光灯.在生物体内,在生物体内.晚期损伤晚期损伤

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